The tripeptide composed of glutamic acid, cysteine, and glycine in its active thiol state
albicans , machine learning and chemogenetic interaction analysis enabled screening of ~6,500 genes, expanding the GRACE (gene replacement and conditional expression) database by 866 entries and revealing 149 fungus-specific essential genes (Fu et al., 2021)
Their development as useful therapeutics, however, has been limited by physiochemical properties that make them susceptible to metabolic degradation and impermeable to gut and blood-brain barriers
doi: 10.1080/0049825021000017902 63 LawsonLDHughesBG
They have demonstrated efficacy in alleviating pain associated with diabetic neuropathy, neuralgia, and low back pain, as well as promoting nerve conduction, making them beneficial for a variety of neurological and pain-related conditions
Faced with ambiguous CMS guidance, these states may choose to continue covering these services while awaiting additional clarity as to whether CMS intends to disallow federal payments (and if so, starting when and as to what age group of Medicaid enrollees) or they may choose to challenge CMS guidance in court
